Efficacy of sodium valproate combined with nimodipine in treatment of patients with subarachnoid hemorrhage and its impact on inflammatory response
Zhang Jie
Zhang Lie
Fan Ying-jun
Zhao Tian-quan
Xia Xun
Abstract：Objective To investigate the efficacy of sodium valproate combined with nimodipine in treatment of subarachnoid hemorrhage(SAH)and its impact on inflammatory response to provide reference for clinical medication.Methods Retrospective analysis of clinical data of 102 SAH patients receiving targeted treatment in The First Affiliated Hospital of Chengdu Medical College from February 2022 to August 2024 was conducted.Meanwhile,these 102 patients were divided into two groups based on differences in medication regimens.The 49 patients in the control group were treated with oral nifedipine,while the other 53 in the observation group were additionally treated with sodium valproate.All the patients in both groups were treated for 3 weeks.The clinical efficacy,National Institutes of Health Stroke Scale(NIHSS)score,seizure rate,middle cerebral artery blood flow velocity,inflammatory factor levels and adverse reactions were compared between the two groups.Results Epileptic seizure rate in the observation group(13.21%(7/53))was lower than that in the control(30.61%(15/49))(χ2=4.559,P<0.05).The total clinical effective rate of the observation group(96.23%(51/53))was higher than that of the control(83.67%(41/49))(χ2=4.537,P<0.05).After treatment,the NIHSS score,middle cerebral artery blood flow velocity,and the level of high-sensitivity C-reactive protein,interleukin-8,tumor necrosis factor-α in the observation group((6.93±1.42)points,(85.67±6.58)cm·s-1,(182.68±21.60)ng·mL-1,(1.46±0.28)ng·mL-1,(0.27±0.06)ng·mL-1)were lower than those in the control((7.79±1.56)points,(94.23±6.74)cm·s-1,(205.43±25.51)ng·mL-1,(2.38±0.32)ng·mL-1,(0.34±0.07)ng·mL-1)(t=2.915,6.448,4.873,15.481,5.435,all P<0.05).No statistical difference was found in overall adverse reaction rate between the two groups(20.75%(11/53)vs 16.33%(8/49))(χ2=0.329,P>0.05).Conclusion In the treatment of SAH,the combi-nation of sodium valproate and nifedipine can improve neurological function,promote cerebral blood flow recovery,prevent epilepsy,reduce inflammatory response,and has high safety profile.
Keywords：Sodium valproateNimodipineSubarachnoid hemorrhageInflammatory responseClinical efficacy
Publication Date：2025-04-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 194-197 )