Clinical efficacy and brain imaging changes of huperzine A combined with xinnao shutong in the treatment of patients with vascular dementia

Dong Fen-fen; Wu Yue; Liu Ting; Qu Fei

doi:10.3969/j.issn.1672-8157.2025.02.001

Abstract：Objective To investigate the efficacy of huperzine A combined with xinnaoshutong in treatmentn of patients with vascular dementia(VD)and its impact on imaging characteristics and cognitive function.Methods A total of 206 patients with VD admitted to Shangluo Central Hospital from March 2021 to June 2023 were divided into the xinnaoshutong group(n=103)and huperperine A combined group(n=103)according to the random number table method.The patients in the xinnaoshutong group were given conventional treatment while those in the huperzine A combined group were treated with huperzine A on the basis of the reg-imen in the xinnaoshutong group.The clinical efficacy,brain imaging changes,cognitive function(MMSE score),dementia degree(HDS score)and daily living ability(ADL score)were compared between the two groups.The safety of treatment was also compared.Results The total effective rate of the huperperine A combined group was 93.21%(96/103),which was higher than that of the xin-naoshutong group(84.47%(87/103))(χ2=3.964,P=0.046).After treatment,the rates of subcortical artery infarction,basal ganglia hemorrhage,parietal lobe infarction,temporal lobe infarction and frontal lobe infarction were 2.91%,4.85%,3.88%,6.80%,5.83%,9.71%,12.62%,11.65%,15.53%and 13.59%in the huperperine A combined group and xinnaoshutong group,respectively.The in-farct rates of the huperzine A combined group and the xinnaoshutong group were lower than those before treatment(22.33%,30.10%,13.59%,19.42%,14.56%,20.39%,25.24%,15.53%,21.36%,17.48%),and the infarction rates of each part of huperzine A combined with Xinnaoshutong group were lower than those before treatment(all P<0.05).The MMSE,HDS and ADL scores of the huperzine A combined group and the xinnaoshutong group were(24.46±4.13)points,(25.65±3.87)points,(66.94±7.21)points,(20.41±3.87)points,(21.06±3.22)points and(58.41±6.57)points respectively.They were higher than those before treatment((18.06±3.47)points,(17.88±2.41)points,(47.51±6.02)points,(17.69±3.52)points,(17.52±2.48)points,(46.84±5.87)points).The scores of the huperzine A combined group were higher than those of the xinnaoshutong group(all P<0.05).The total incidence of adverse reactions was 16.50%(17/103)in the xinnaoshulong group and 19.41%(20/103)in the huperperine A combined group,showing no significant difference between the two groups(χ2=0.296,P>0.05).Conclusion Huperzine A combined with Xinnaoshutong is more conducive to improve cognitive function,dementia degree and daily living ability in patients with vascular dementia.The cerebral image changes are better and the clinical efficiency is more significant.Additionally,it is of high safety.