Analysis of 85 cases of adverse reactions caused by methylprednisolone injection in treatment of children with respiratory diseases
Huang Bin
Shi Cheng
Abstract：Objective To analyze the adverse reactions(ADRs)caused by methylprednisolone injection in the treatment of respiratory diseases in children.Methods A total of 85 pediatric patients with respiratory diseases treated in Tongling Maternal and Child Health Hospital from July 2022 to June 2024 were retrospectively selected as the research subjects and divided into the occurrence group(n=31)and non-occurrence group(n=54)according to whether adverse reactions occur after treatment with methyl-prednisolone injection.The general information of patients was collected,and the influencing factors of adverse reactions in patients were analyzed using single factor and multifactor logistic regression.Results The alkaline phosphatase(ALP)level,leukocyte level,C-reactive protein(CRP)level,single dose,total dose and medication time in the occurrence group were(123.72±9.30)U·L-1,(13.65±3.13)×109·L-1,(8.98±2.89)mg·L-1,(2.53±0.27)mg·kg-1,(12.95±2.18)mg and(6.44±2.04)d,which were all lower than those of(118.63±9.49)U·L-1,(11.95±3.17)×109·L-1,(7.65±2.54)mg·L-1,(1.44±0.16)mg·kg-1,(11.02±2.14)mg and(3.46±1.04)d in the non-occurrence group(all P<0.05).Logistic regression analysis showed that ALP level(P=0.030),leukocyte level(P=0.011),CRP level(P=0.022)and medication time(P=0.002)were all influencing factors for ADRs caused by MP injection in treatment of respi-ratory diseases in children.Conclusion ALP level,leukocyte level,CRP level,single dose,total dose and medication duration are all influencing factors for ADRs caused by methylprednisolone injection in the treatment of respiratory diseases in children.
Keywords：Methylprednisolone injectionPediatric respiratory diseaseAdverse reactionLogistic regression analysis
Publication Date：2025-02-24
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 166-169 )