Analysis of adverse reactions caused by methimazole in treatment of 214 cases of hyperthyroidism

Zhao Li-ying; Wen Chun-cheng; Shen Ling; Jiang Fu-rong

doi:10.3969/j.issn.1672-8157.2025.01.037

Abstract：Objective To analyze the adverse reactions(ADRs)of methimazole in the treatment of hyperthyroidism and pro-vide reference for clinical medication.Methods A retrospective study method was used to collect data on patients with hyperthy-roidism treated with methimazole in Santai Hospital Affiliated to North Sichuan Medical College from April 2021 to February 2023,and the use of methimazole during treatment was recorded and counted.The severity and counter-measures of the adverse reactions were discussed.Results In 930 patients with hyperthyroidism treated with methimazole,214 patients developed ADR and 716 did not,and the incidence of ADR was 23.01%.Among the 214 patients with ADRs,48 were male(22.43%)and 166 female(77.57%).The number of female patients was higher than that of male ones(χ2=130.131,P<0.05).The age was mainly between 10 and 20(26.64%),21-35(36.45%),36-50(20.09%).The percentage of patients between 10 and 50(83.18%)was higher than that of patients under 10 years old and over 50 years old(16.82%)(χ2=188.450,P<0.05).A total of 424 ADRs occurred in the 214 patients and they were mainly skin reactions in 139 cases(32.78%),musculoskeletal system reactions in 103(24.29%)and gastrointestinal system reactions in 97(22.88%).Conclusion Hyperthyroidism patients treated in Santai Hospital Affiliated to North Sichuan Medical College are generally aged between 10 and 50 and the ADRs mostly occur in females.The most common ADRs are found in skin,skeletal muscle and gastrointestinal system.Occasionally,serious ADRs such as granulocyte deficiency and liver damage may occur,and corresponding treatment measures should be taken based on the patient's condition.