Efficacy of gardenia licorice and black bean paste combined with rabeprazole in treatment of bile reflux gastritis
Ye Mao-gao
Zhang Wei-wei
Gao Sai-sai
Abstract：Objective To explore the clinical efficacy of gardenia licorice and black pepper decoction combined with rabep-razole in the treatment of bile reflux gastritis(BRG).Methods Eighty-nine BRG patients admitted to Wenzhou Hospital of Inte-grated Traditional Chinese and Western Medicine from January 2023 to December 2023 were selected for retrospective analysis and divided into the combination group(n=51)and the single-drug group(n=38)according to the difference in treatment methods.The patients in the single-drug group were given rabeprazole sodium enteric-coated capsules for oral administration,while those in the combination group were given gardenia licorice and black bean soup flavored.All the patients in both groups were treated continu-ously for 8 weeks.The clinical efficacy,adverse reactions,the TCM syndrome scores and serum interleukin(IL)-6,IL-8,and gastrin(GAS)levels were compared between the two groups before treatment and after 8 weeks of treatment.Results After 8 weeks of treatment,the total effective rate of the combination group was 90.20%(47/51),which was higher than 73.68%(28/51)of the sin-gle-drug group(χ2=5.605,P<0.05).TCM syndrome scores and serum IL-6,IL-8,and GAS levels in the combined group(respectively(8.52±1.36)points,(15.43±3.16)mmol·L-1,(10.21±1.52)ng·L-1,(85.26±7.33)ng·L-1)were lower than those in the single-drug group(respectively(14.17±1.89)points,(18.72±3.88)mmol·L-1,(14.03±2.37)ng·L-1,(97.58±9.17)ng·L-1)(t=16.407,4.406,9.246,7.042,all P<0.05).There was no difference in the incidence of adverse reactions between the two groups(9.80%vs 13.15%,χ2=0.024,P>0.05).Conclusion Gardenia licorice and fermented soup combined with rabeprazole has good clinical efficacy in the treatment of BRG.It can effectively relieve patients'symptoms,reduce the level of patients'inflammatory factors,correct gastrin disorders,and is safe and controllable.
Keywords：Bile reflux gastritisFlavored gardenia licorice and black bean soupRabeprazoleClinical efficacySafety
Publication Date：2025-02-24
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 124-127 )