Efficacy of mosapride combined with bupleurum shugan powder in treatment of gastroesophageal reflux(qi stagnation and phlegm obstruction syndrome)in elderly patients
Luo Feng-yan
Yan Hui-min
Ma Wei
Abstract：Objective To explore the efficacy of mosapride combined with bupleurum shugan powder in the treatment of gastroesophageal reflux(GERD)(called qi stagnation and phlegm obstruction syndrome in Traditional Chinese Medicine).Methods The random number table method was used to divide 104 GERD patients admitted to Beijing Longfu Hospital from June 2021 to July 2024 into the control group(treated with mosapride)and the observation group(treated with mosapride combined with bupleurum shugan powder),with 52 in each group.The clinical efficacy,TCM symptom scores,gastroesophageal reflux disease scale(Gerd-Q)scores,serum gastrointestinal hormone levels and incidence of adverse reactions were compared between the tgwo groups.Results The total effective rate was higher in the observation group than in the control(94.23%(49/52)vs 80.77%(42/52))(χ2=4.308,P<0.05).The TCM symptom score and Gerd-Q score of the observation group after treatment were(6.82±1.76)points and(6.32±1.68)points and they were lower than those of the control((10.13±2.09)points,(8.89±1.75)points)(t=8.736,7.640,both P<0.05).The level of vasoactive intestinal peptide(VIP)of the observation group after treatment was(17.37±3.20)pg·mL-1,which was lower than that of(24.92±3.34)pg·mL-1 in the control(t=11.770,P<0.05),and the level of gastrin(GAS),motilin(MTL)((68.42±5.54)pg·m L-1,(256.16±24.84)pg·mL-1,respectively)were higher than those in the control((56.21±5.76)pg·mL-1,(214.58±23.61)pg·mL-1,respectively)(t=11.017,8.749,both P<0.05).There was no statistically significant difference in incidence of adverse reactions between the two groups(11.54%(6/52)vs 15.38%(8/52))(χ2=0.330,P>0.05).Conclusion Mosapride combined with bupleurum shugan powder can significantly improve the efficacy of GERD in elderly patients with qi stagnation and phlegm obstruction since it can effectively regulate gastrointestinal hormone levels,promote gastrointestinal function recovery and relieve related symptoms and signs.Meanwhile,it is of good safety.
Keywords：MosaprideBupleurum shugan powderGastroesophageal refluxQi depression and phlegm obstruction syndromeElderlyClinical efficacy
Publication Date：2025-02-24
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 120-123 )