Efficacy of cyclosporine combined with sodium hyaluronate in treating patients with moderate to severe dry eye disease

Guo Jia-wei; Liu Yu-zhe

doi:10.3969/j.issn.1672-8157.2025.01.020

Abstract：Objective To explore the clinical effectiveness of combining cyclosporine with sodium hyaluronate in the man-agement of patients suffering from moderate to severe dry eye syndrome.Methods A total of 96 patients with moderate to severe dry eye admitted to Nanjing Tongren Hospital from March 2021 to March 2024 were selected.According to the treatment methods,these patients were divided into a control group(treated with sodium hyaluronate)and an observation group(treated with cyclo-sporine combined with sodium hyaluronate),with 48 in each group.The treatment effects,the corneal fluorescence staining(CFS)score,ocular surface disease index(OSDI)score,tear film breakup time(BUT),tear river height(TMH),tear secretion test(SIT)and conjunctival congestion before and after treatment were compared between the two groups.Results The effective rate of the observation group was 93.75%(45/48),which was higher than that of 79.17%(38/48)in the control(χ2=4.360,P<0.05).The CFS,OSDI,and conjunctival congestion scores were all reduced after treatment in both groups,and the CFS((1.56±0.32)points vs(2.72±0.51)points),OSDI((20.91±4.36)points vs(20.91±4.36)points vs(27.28±4.42)points)and conjunctival congestion((1.12±0.25)points vs(1.39±0.32)points)were lower than those of the control group(t=3.348,7.108,4.607,all P<0.05).The BUT,TMH and SIT of the two groups of patients with moderate to severe dry eye after treatment were all higher than before treatment,and the BUT of the observation group((5.14±1.06)s vs(3.96±1.17)s),TMH((0.29±0.06)mm vs(0.20±0.05)mm)and SIT((5.46±1.62)mm·5 min-1 vs(4.53±1.34)mm·5 min-1)were higher than those in the control group(t=5.178,7.984,3.065,all P<0.05).Conclusion Treatment with cyclosporine combined with sodium hyaluronate is effective in patients with moderate to severe dry eye syndrome since it can effectively promote the recovery of tear film stability and relieve dry eye symptoms.