Efficacy of kangfuxin liquid combined with thymosin in treatment of pulmonary tuberculosis and its impact on immune function in elderly patients
Ma Jun-ke
Zhang Jing
Wang Shi-yan
Cui Jun-wei
Abstract：Objective To explore the efficacy of kangfuxin liquid combined with thymosin in treatment of pulmonary tuberculo-sis and investigate its effect on immune function in elderly patients.Methods A total of 117 elderly patients with pulmonary tuber-culosis treated in the First Affiliated Hospital of Xinxiang Medical College from January 2020 to February 2023 were retrospectively selected and divided into an observation group of 62 cases and a control group of 55 cases according to the treatment methods.The patients in the control group received kangfuxin liquid treatment,and those in the observation group received treatment with kangfuxin liquid combined with thymosin for 6 months.The curative effect,immune function,lung function and changes in inflammatory fac-tors were compared between the two groups.Results After 6 months of treatment,the total effective rate of the observation group was 83.87%(52/62),which was higher than 64.15%(34/55)of the control(χ2=5.892,P<0.05).After treatment,the levels of CD3+,CD4+,CD4+/CD8+,FEV1/FVC,PEF,FVC,and IFN-γ in both groups were increased while those of CD8+,CRP and IL-6 decreased as compared with those before treatment(all P<0.05).The levels of CD3+,CD4+,CD4+/CD8+,forced expiratory volume in 1 second(FEV1)/forced vital capacity(FVC),peak forced expiratory flow(PEF),FVC,interferon gamma(IFN-γ)were significantly higher in the observation group than in the control((66.76±3.22)%vs(64.03±3.15)%,(34.02±3.47)%vs(30.02±3.25)%,(1.27±0.29)%vs(1.14±0.22)%,(84.64±10.67)%vs(75.44±10.13)%,(81.28±13.66)pg·mL-1 vs(70.13±11.85)pg·mL-1,(3.51±0.68)L vs(2.67±0.62)L,(35.59±3.10)ng·L-1 vs(28.43±3.56)ng·L-1)(t=4.624,6.411,2.705,4.767,4.687,6.950,11.629,all P<0.05).However,the levels of CD8+,CRP and IL-6 were lower in the observation group than in the control((27.67±2.78)%vs(31.18±3.08)%,(11.47±2.31)mg·L-1 vs(16.16±2.45)mg·L-1,(23.67±2.35)pg·mL-1 vs(29.13±2.44)pg·mL-1)(t=6.479,10.653,12.319,all P<0.05).Conclusion Kangfuxin liquid combined with thymosin can improve the efficacy and immune function of elderly patients with pul-monary tuberculosis by promoting the lung function and reducing inflammation factor levels.
Keywords：Kangfuxin liquidThymosinTuberculosisEfficacyLung functionImmune functionInflammatory factor
Publication Date：2025-02-24
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 43-46 )