Effect of bifidobacterium triple viable bacteria on immune function and intestinal microecology in patients undergoing postoperative chemotherapy for gastric cancer
Wu Zu-guang
Deng Quan-jun
Meng Xiao-ru
Hou Yang-kun
Abstract：Objective To investigate the effect of bifidobacterium triple viable bacteria capsule on immune function and intestinal microecology of patients receiving postoperative chemotherapy for gastric cancer.Methods A total of 102 patients un-dergoing postoperative chemotherapy for gastric cancer in Special Medical Center of Armed Police Force from March 2023 to May 2024 were selected as the research subjects and dvided into the nutrition group and live bacteria group by using the random number table method,with 51 in each group.The patients in the nutrition group were given early enteral nutrition therapy while those in the live bacteria group were given bifidobacteria triple live bacteria based on early enteral nutrition therapy.The levels of the inflam-matory factors,immune function indicators,intestinal microecological flora,curative effect and adverse reactions were compared between the two groups.Results After treatment,the levels of interleukin-1β(IL-1β),transforming growth factor-β(TGF-β),in-terleukin-2(IL-2),CD8+,Lactobacillus,Bifidobacterium,Enterococcus faecalis,and Bacteroides in the probiotics group((35.29±6.83)ng·mL-1,(9.78±2.15)pg·mL-1,(15.24±3.72)ng·mL-1,(39.68±6.91)%,(5.12±1.36)Ig CFU·mL-1,(4.95±1.02)Ig CFU·mL-1,(4.37±1.15)Ig CFU·mL-1,(7.89±2.14)Ig CFU·mL-1)were lower than those in the nutrition group((50.17±8.46)ng·mL-1,(21.69±3.84)pg·mL-1,(30.16±4.65)ng·mL-1,(50.17±6.85)%,(10.63±2.25)Ig CFU·mL-1,(13.81±2.28)Ig CFU·mL-1,(10.24±2.65)Ig CFU·mL-1,(16.32±2.56)Ig CFU·mL-1,respectively)(t=11.237,19.327,17.839,7.699,14.967,25.332,14.511,18.043,all P<0.05).The levels of immunoglobulin M(IgM),immunoglobulin G(IgG),immunoglobulin A(IgA),CD4+,CD4+/CD8+,and Esch-erichia coli in the probiotics group((3.87±0.95)g·L-1,(39.86±4.72)g·L-1,(5.35±0.95)g·L-1,(71.52±8.67)%,(1.80±0.32),(25.76±3.49)Ig CFU·mL-1)were higher than those in the nutrition group((2.56±0.43)g·L-1,(25.15±3.59)g·L-1,(3.98±0.82)g·L-1,(59.34±9.21)%,(1.18±0.25),(12.95±2.83)Ig CFU·mL-1,respectively)(t=8.971,17.715,7.796,6.877,10.904,20.360,all P<0.05).The overall effective rate after treatment was higher in the probiotics group(82.35%,42/51)than in the nutrition group(52.98%,27/51)(χ2=10.079,P<0.05).The incidence of adverse reactions was lower in the probiotics group(3.92%,2/51)than in the nu-trition group(17.65%,9/51)(χ2=4.993,P<0.05).Conclusion Bifidobacterium triple viable bacteria capsule can reduce the incidence of inflammatory reaction and adverse reactions,improve immune function and intestinal microecology,and promote the curative effect.
Keywords：Bifidobacterium triple viable bacteriaEarly enteral nutritionGastric cancerChemotherapyImmune functionIn-testinal microecology
Publication Date：2025-02-24
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 38-42 )