Efficacy of levetiracetam combined with clonazepam in treatment of focal epilepsy and its impact on bone metabolism in children
Tang Hua-li
Deng Jun
Wang Fei
Abstract：Objective To investigate the efficacy of levetiracetam combined with clonazepam in treatment of focal epilepsy and its influence on bone metabolism in children.Methods A total of 121 children with focal epilepsy treated in Guilin Maternal and Child Health Hospital from July 2022 to June 2024 were selected as the research subjects and divided into the observation group(n=63)and the control group(n=58)according to the treatment method.The patients in the control group received levetiracetam monotherapy while those in the observation group received levetiracetam combined with clonazepam for 3 months.The therapeutic efficacy,bone metabolism,bone density,seizures and adverse reactions were compared between the two groups.Results After treatment,the total effective rate of the observation group was higher than that of the control(93.65%vs 81.03%)(χ2=4.426,P<0.05).In the observation group,the bone mineral density(BMD)of the Ward triangle,lumbar spine and femoral neck was lower than before treatment((0.44±0.04)g·cm-2 vs(0.54±0.06)g·cm-2,(0.59±0.07)g·cm-2 vs(0.66±0.11)g·cm-2,(0.55±0.11)g·cm-2 vs(0.63±0.12)g·cm-2)(t=11.007,4.261,3.901,all P<0.05).In the control group,the BMD of the Ward triangle,lumbar spine and femoral neck was also lower than before treatment((0.42±0.05)g·cm-2 vs(0.53±0.04)g·cm-2(0.58±0.08)g·cm-2 vs(0.64±0.13)g·cm-2,(0.53±0.10)g·cm-2 vs(0.62±0.15)g·cm-2)(t=13.083,2.994,3.802,all P<0.05).The BMD of the Ward triangle was higher in the observa-tion group than in the control((0.44±0.04)g·cm-2 vs(0.42±0.05)g·cm-2)(t=2.439,P<0.05).Meanwhile,the number and duration of epileptic seizures in the observation group were less than those in the control group after treatment((4.42±1.15)times per month vs(3.04±1.24)times per month,(6.58±1.58)min vs(5.21±1.37)min)(P<0.05).The difference in the incidence of adverse reactions was not statistically significant between the two groups(12.70%vs 12.07%)(χ2=0.011,P>0.05).Conclusion Levetiracetam combined with clonazepam can improve the efficacy,shorten the duration of epilepsy and reduce the number of seizures in children with focal epilepsy without enhancing the adverse effects on bone metabolism.
Keywords：LevetiracetamClonazepamFocal epilepsyEfficacyBone metabolism
Publication Date：2025-02-24
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 9-12 )