Efficacy and safety of Lugua polypeptide combined with percutaneous pedicle screw fixation in patients with thoracolumbar burst fractures
Pei Jin-le
Wang Hai-yu
Liu Nian
Tong Lei
Fu Yong-li
Ding Yuan-fei
Li Du
Cheng Long
Abstract：Objective To investigate the effectiveness and safety of percutaneous pedicle screw fixation in conjunction with Lugua polypeptide in patients suffering from thoracolumbar burst fractures. Methods A total of 82 patients with thoracolumbar burst fractures admitted to Nanyang Central Hospital from March 2022 to March 2024 were selected and divided into the Lugua polypeptide combination group and the surgical fixation group using the random number table method,with 41 in each group. All the patients in both groups underwent percutaneous pedicle screw fixation,and those in the Lugua polypeptide combined group received treatment with Lugua polypeptide for 15 days in addition. The visual analog scores,bone metabolism indexes,Oswestry disability index,vertebral body height ratio and kyphosis angle,and occurrence of adverse reactions were compared between the two groups. Results After treatment,the visual analogue scale and Oswestry disability index were remarkably decreased but the levels of β-collagen carboxy-terminal cross-linked peptide (β-CTX),type I collagen amino-terminal propeptide (PINP),and osteocalcin (BGP) increased in both groups ( P<0.05). Moreover,the Cobb angles were all reduced (P<0.05). The VAS score and Oswestry dysfunc-tion index were significantly lower while β-CTX,PINP and BGP levels higher in the Lugua polypeptide combined group than in the surgical fixation group ((0.79±0.23) points vs (0.96±0.34) points,(23.24±7.25)％ vs (28.26±9.33)％,5.26±0.89) ng·mL-1 vs (4.87±0.78) ng·mL-1,(234.61±26.15) μg·mL-1 vs (221.84±23.10) µg·mL-1,(31.89±5.04) ng·mL-1 vs (28.65±4.97) ng·mL-1) (t=2.652,2.720,2.110,2.343,2.931,all P<0.05). The height ratio of the anterior and posterior edges of the vertebral bodies was not significantly dif-ferent between the two groups ((50.06±8.23)％ vs (49.34±8.07)％,(63.81±7.99)％ vs (65.06±8.59)％,P>0.05). Meanwhile,there were no statistically significant differences in Cobb angle and incidence of adverse reactions after treatment between the two groups ((4.36±0.89)° vs (4.56±0.93)°,19.51％ vs 12.20％) (t=1.489,1.123,0.995,x2=0.823,P>0.05). Conclusion Lugua polypeptide combined with percutaneous pedicle screw fixation can reduce pain and lumbar dysfunction in patients with thoracolumbar burst fractures and improve bone metabolism without affecting the safety of the treatment.
Keywords：Thoracolumbar burst fracturePercutaneous pedicle screw fixationLugua polypeptideBone metabolism indexOswestry disability index
Publication Date：2024-12-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 805-808 )