Ginkgolide injection for adjuvant therapy of acute cerebral infarction in elderly patients

He Chun-hui; Dai Qi-jun; Chen Jun

doi:10.3969/j.issn.1672-8157.2024.06.010

Abstract：Objective To explore the curative efficacy of ginkgolide injection for adjuvant therapy of acute cerebral infarction (ACI) in elderly patients. Methods A total of 86 patients with ACI admitted to Hai'an Hospital of Traditional Chinese Medicine from January 2020 to January 2023 were enrolled as the research objects. According to the random number table method,these pa-tients were divided into the control group (n=43,routine treatments:oral aspirin and clopidogrel bisulfate) and the observation group (n=43,ginkgolide injection in addition to the regimen in the control group). All the patients in both groups were treated for 14 days. The clinical curative effect,vascular endothelial function (endothelin (ET-1),nitric oxide (NO)),hemorheology (whole blood viscos-ity (WBV),fibrinogen (FIB),plasma viscosity (PV)) and nerve function (national institute of health stroke scale (NIHSS),modified Rankin scale (mRS)) before and after treatment were compared betweend the two groups. The adverse reactions were also recorded. Results There were significant differences in total response rate between observation group and control group (95.35％ vs 79.07％,x2=5.108,P=0.024). After treatment,levels of serum ET-1,WBV,FIB and PV,scores of NIHSS and mRS were decreased in both groups,and they were lower in the observation group (P<0.05),while level of serum NO was significantly increased,which was higher in the observation group (P<0.05). There was no significant difference in the incidence of adverse reactions between the observation group and control group during treatment (9.30％ vs 6.98％,x2=0.156,P=0.693). Conclusion Ginkgolide injection for adjuvant ther-apy can improve clinical curative effect,hemorheology,vascular endothelial function and nerve function in patients with ACI.