Effect of radioiodine therapy on thyroid function and T lymphocytes in patients with Graves'disease
Wei Xiao-Hua
Li Xu
Du Xiao-Yang
Abstract：Objective To explore the effects of radioactive iodine treatment on thyroid function and T lymphocyte function in patients with Graves'disease. Methods A total of 137 patients diagnosed with Graves'disease and treated in Anyang Regional Hospital of Puyang City from January 2023 to June 2024 were selected for the study. According to different treatment methods,these patients were divided into the observation group (n=76,treated with 131Ⅰ) and the control group (n=61,treated with methimazole). Clinical efficacy,thyroid function,and changes in T lymphocyte function were compared between the two groups and the correla-tion of thyroid function to T lymphocyte changes was analyzed. Results The effective rate in the observation group was 89.47％ (68/76),which was significantly higher than that of 73.77％ (45/61) in the control (x2=5.775,P=0.016). One month and three months after treatment,the FT3 and FT4 levels in both groups were remarkably decreased while TSH levels increased (P<0.05). One month after treatment,the FT4 level in the observation group was lower than that in the control (t=5.455,P<0.001). Three months after treatment,the FT3 and FT4 levels in the observation group were lower than those in the control (t=7.794,2.775,both P<0.05),and the TSH level was higher than that in the control (t=2.965,P=0.004). One month and three months after treatment,the proportion of CD3+T cells in both groups was obviously increased,while the proportion of CD4+T cells decreased one month after treatment and increased three months after treatment (P<0.05). Three months after treatment,the proportion of CD3+T cells in the observation group was higher than that in the control,and the proportion of CD4+T cells was lower in the observation group (t=3.780,2.775,both P<0.05). The proportion of CD4+T cells was positively correlated with FT3,FT4,and TSH levels (r=0.453,0.495,0.594,all P<0.05),and the CD4+/CD8+ratio was also positively correlated with FT3,FT4,and TSH levels (r=0.512,0.592,0.474,all P<0.05). Conclusion 131Ⅰ treatment for Graves'disease is more effective than methimazole treatment,and it can improve thyroid function and affect immune function. During 131Ⅰ treatment for Graves'disease,attention should be paid to the relevant indicators of thyroid function and immune function.
Keywords：Radioactive iodine treatmentGraves'diseaseThyroid functionImmune functionLymphocyte
Publication Date：2024-12-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 708-712 )