Systematic evaluation of denosumab for treatment of osteoporotic fractures
Mi Ling-bin
Zhao Zhen-yu
Jiang Li-jun
Liu Tie-long
Abstract：Objective To evaluate the efficacy,safety and economics of denosumab in the treatment of diseases associated with osteoporotic fractures.Methods A systematic search was conducted on databases of CNKI,Weipu,Wanfang and,SinoMed in China from January 2019 to May 2024.PubMed,Web of science and Cochrance Library databases were randomly searched for denosumab in the treatment of osteoporotic fractures.Controlled trials were conducted to study the literaure,and the included literature was systematically reviewed.Results Denosumab significantly reduced the risk of fractures(especially hip fracture)and exerted a significant effect on bone mineral density.However,some adverse effects including influenza-like reactions and hypocalcemia have been observed for denosumab.In terms of economics,denosumab demonstrated a desirable profile.However,further studies are needed to determine its long-term efficacy and safety.Conclusion Denosumab is an effective drug for the treatment of osteoporotic fractures,but its potential adverse effects and economic burden should be carefully paid attention to in clinical use.
Keywords：DenosumabOsteoporosisFractureSystematic evaluationMeta-analysis
Publication Date：2024-08-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 489-493 )