Efficacy of meglumine adenosine cyclophosphate combined with Wenyang Xiefei Baoxin decoction in treatment of chronic cor pulmonale complicated with congestive heart failure in elderly patients and its impact on hemorheological indicators
Zhao Qiu-mei
Wang Ning
Jiang Wen-wen
Nie Wei
Feng Xue-ming
Lu Ying
Niu Xiao-zu
Abstract：Objective To investigate the efficacy of cyclic adenosine monophosphate combined with Wenyang Xiefei Baoxin decoction in treatment of elderly patients with chronic cor pulmonale complicated with heart failure and its impact on hemorheological indicators.Methods A total of 102 elderly patients with cor pulmonale complicated with heart failure admitted to Huaibei Hospital of Traditional Chinese Medicine from May 2021 to May 2023 were enrolled in this study.Using a random red and blue ball drawing method,these patients were divided into an observation group(red ball,n=51)and a control group(blue ball,n=51).The patients in the control group were treated with meglumine adenosine cyclophosphate while those in the observation group were given Wenyang Xiefei Baoxin decoction on the basis of the regimen in the control group.The changes in TCM syndromes score,clinical efficacy,myocardial injury(brain natriuretic peptide(BNP),cardiac troponin T(cTnT)),pulmonary function(forced expiratory volume in one second(FEV1),forced expiratory volume to forced vital capacity ratio(FEV1/FVC))and hemorheological indicators(whole blood viscosity at low shear rate(WBVL),whole blood viscosity at high shear rate(WBVH),platelet aggregation rate(PAR),red blood cell aggregation index(RAI))were compared between the two groups before and after treatment.Results After treament,the total effective rate in the observation group was 90.20%(46/51),which was higher than 68.63%(35/51)in the control(χ2=7.256,P<0.05).Both groups showed significant reductions in myocardial injury markers:plasma BNP((873.34±145.66)pg·mL-1 vs(981.89±234.98)pg·mL-1)and serum cTnT((12.24±2.35)ng·mL-1 vs(13.76±3.01)ng·mL-1),hemorheological indicators WBVL、WBVH,PAR,RAI((9.21±1.34)mPa·s,(4.34±2.19)mPa·s,(40.13±4.77)%,(2.19±1.11)vs(9.86±1.08)mPa·s,(5.31±1.38)mPa·s,(42.96±5.14)%,(2.78±1.02)),and TCM syndrome score,shortness of breath upon exertion,facial and limb edema,palpitations with spontaneous sweating,and cyanotic lips((1.08±0.13),(1.34±0.35),(1.23±0.57),(1.35±0.65)vs(1.24±0.44),(1.51±0.19),(1.55±0.39),(1.68±0.38))compared to pre-treatment levels,with the observation group showing lower levels than the control(P<0.05).Both groups demonstrated improvements in pulmonary function indicators:FEV1((1.88±0.78)L vs(1.54±0.44)L)and FEV1/FVC ratio((67.24±4.56)vs(64.77±4.11)),with the observation group showing higher values than the control group(P<0.05).Conclusion The combination of cyclic adenosine monophosphate with Wenyang Xiefei Baoxin decoction demonstrates significant efficacy in treating elderly patients with cor pulmonale complicated with heart failure.This treatment markedly improves clinical symptoms,enhances cardiac and pulmonary function and promotes normalization of hemorheological indicators.
Keywords：Meglumine adenosine cyclophosphateWenyang Xiefei Baoxin decoctionElderly chronic pulmonary heart diseaseHeart failureHemorheology
Publication Date：2024-08-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 462-467 )