Therapeutic efficacy of compound Xuanju capsule combined with metformin in patients with obese polycystic ovary syndrome
Wei Xin-fang
Guo Min
Abstract：Objective To investigate the therapeutic efficacy of compound Xuanju capsule combined with metformin in patients with obese polycystic ovary syndrome(OPCOS).Methods A total of 172 patients with OPCOS admitted to our hospital were randomized into the study group and the control group,with 86 in each.The patients in the control group were treated with metformin and those in the study one with the compound Xuanju capsule in addition to metformin.Then the clinical efficacy,blood lipid profile,sex hormone levels,ovarian stimulation and adverse effects were compared between the two groups.Results After receiving treatment,the total effective rate of the study group was significantly higher than that of the control(91.86%vs 72.09%,P<0.05).The improvement of high-density lipoprotein cholesterol,total cholesterol,triacylglycerol,and low-density lipoprotein cholesterol in the study group was more obvious than that in the control((2.29±0.32,3.36±0.51,1.17±0.37,1.57±0.47)vs(2.04±0.28,4.57±0.66,1.56±0.33,2.61±0.58)mmol·L-1,all P<0.05).As compared with the control group,the levels of luteinizing hormone and testosterone in the study one were decreased significantly((6.16±1.23 vs 9.23±1.38)IU·L-1,(1.27±0.35 vs 1.86±0.43)nmol·L-11,both P<0.05)and the levels of estradiol and follicle-stimulating hormone increased more obviously((95.32±13.56 vs 82.70±11.15)pg·mL-1,(9.11±1.09 vs 7.48±1.22)IU·L-1,both P<0.05).The endometrial thickness and number of mature follicles in the study group((1.02±0.21)cm,(2.18±0.22))were higher than those in the control((0.76±0.25)cm,(1.53±0.26))(both P<0.05).while the number of ovulation induction days in the study group was less than that in the control(9.47±0.54 vs 13.39±1.38)(P<0.05).The difference in adverse reactions between the two groups was not statistically significant(11.63%vs 13.95%,P>0.05).Conclusion Application of compound Xuanju capsule combined can effectively stimulate the ovulation,regulate the sex hormone and improve the blood lipid profile in patients with OPCOS.
Keywords：Compound Xuanju capsuleMetforminObesityPolycystic ovary syndromeBlood lipidOvulation
Publication Date：2024-04-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 172-175 )