Analysis of therapeutic drug monitoring results for levetiracetam and its use in critically ill patients
Wang Rong-rong
Cai Le
Li Rong-yan
Chen Meng-li
Wang Tian-lin
Abstract：Objective To analyze the characteristics of levetiracetam TDM and provide references for the rational drug use in critically ill patients.Methods Blood concentration monitoring data and case data were collected from March 2021 to August 2022.The treatment plan of levetiracetam and the trough and peak concentrations were analyzed,the influencing factors of blood concentration were discussed.Results A total of 64 cases of levetiracetam TDM were collected,including 36 cases of trough concentration and 28 cases of peak concentration,and only 36.1%of the trough concentration reached the standard.52.8%of the patients were critically ill patients,and 76.9%of the critically ill patients had ARC.Critically ill patients may have more severe ARC in the 1.5 g q 12 h non-standard group.Conclusion In clinical practice,the blood concentration of levetiracetam has a low compliance rate.For critically ill patients,attention should be paid to identify ARC,and adjust the dosage according to TDM and Ccr individually.
Keywords：LevetiracetamTDMCritically ill patientsARC
Publication Date：2024-02-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 73-75 )