Effect of rifampicin combined with compound neotamine on proinflammatory factors in patients with retreated smear-positive pulmonary tuberculosis
Chen Qiao-ling
Chen Xin
Ye Zi
Luo Qing
Xia Xu-hui
Liu Fa-bin
Wang Chao-xiu
Liu Xin
Chen Ming-hui
Abstract：Objective To analyze the curative effect of rifampicin combined with compound neotamine in patients with retreated smear-positive pulmonary tuberculosis and its effect on serum levels of proimflammatory factors.Methods Eighty patients with retreated smear-positive pulmonary tuberculosis admitted to our hospital from May 2017 to August 2022 were randomly divided into observation group and control group by sealed envelopes.The control group was treated with rifampicin,while the observation group was treated with rifampicin combined with compound nectarine.After treatment,the clinical efficacy,recurrence rate and sputum negative conversion rate were evaluated,and the levels of HP(haptoglobin),IL-37(Interleukin-37)and OPN(osteopontin)in serum were detected before and after treatment.Results After treatment,the absorption rate of lesions in the observation group was significantly higher than that in the control group(P<0.05);the cavity shrinkage rate in the observation group was significantly higher than that in the control group(P<0.05);the recurrence rate of the observation group was significantly lower than that of the control group(P<0.05),and the sputum negative conversion rate was significantly higher than that of the control group(P<0.05).The prognosis of the observation group was significantly higher than that in the control group(P<0.05);the levels of IL-37,HP and OPN in both groups significantly decreased after treatment(P<0.05),the levels of IL-37,HP and OPN in the observation group were(4.63±0.83)pg·mL-1,(810.38±31.64)μg·mL-1,(189.19±20.74)pg·mL-1 in the control group were(6.33±0.91)pg·mL-1,(1283.73±101.67)μg·mL-1,(456.28±45.92)pg·mL-1 respectively,and the differences were statistically significant(P<0.05).The average was significantly lower than that of the control group(P<0.05).Conclusion Rifampicin combined with compound neotamine can improve the clinical efficacy of retreated smear-positive pulmonary tuberculosis patients,and significantly improve the levels of IL-37,HP and OPN in blood.
Keywords：RifampicinCompound neotamineRetreatment smear-positive tuberculosisHaptoglobininterleukin-37Osteopontin
Publication Date：2024-02-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 17-20 )