Efficacy of drug-loaded microspheres combined with iodinated oil TACE and apatinib in the treatment of primary liver cancer
Xue Feng-hua
Zhu Lin
Zhang Shu
Zhang Fei-fei
Wang Qing-dong
Zhang Chao
Abstract：Objective To investigate the efficacy of drug-loaded microspheres combined with transcatheter arterial chemoembolisation with iodinated oil(transarterial chemoembolization,TACE)and apatinib in primary hepatocellular carcinoma(primary hepatic carcinoma,PHC).Methods A total of 136 PHC patients meeting the criteria were selected and divided into two groups.The study group(n = 89)was treated with drug-loaded microspheres in combination with iodinated oil TACE and apatinib.The control group(n = 47)was treated with iodinated oil TACE combined with apatinib.Differences in efficacy,liver function,tumour-related indexes,adverse reactions,and prognosis were compared between the 2 groups.Results Before treatment,the differences in the indicators were not of statistical interest(P>0.05).Liver function indices were higher in both groups after treatment compared to before treatment[TBIL(25.9±3.6)vs(25.6±3.5)μmol·L-1,ALT(72.5±7.6)vs(71.9±7.2)U·L-1,AST(58.5±4.6)vs(58.8±4.2)U·L-1](t = 3.326、3.219,4.182,4.110,3.281,3.261,P = 0.032,0.036,0.027,0.030,0.032,0.035),but the difference between groups was not statistically significant(t = 1.282、1.227,1.362,P = 0.288,0.182,0.362).Improvement in tumour indices was even greater in the study group after treatment[HIF-1α(112.1±16.2)vs(158.8±18.4)pg·mL-1,AFP(130.1±22.2)vs(192.4±29.4)ng·mL-1](t = 3.330、4.315,P = 0.037,0.025).The adverse event rate of the two groups after therapy was not significant(P>0.05);the overall survival rate of the study group was higher than that of the control group after the operation(80.9%vs.63.8%)(P<0.05).Conclusion Drug-eluting microspheres combined with iodized oil TACE and apatinib showed better efficacy in patients with PHC without increasing liver toxicity or adverse reactions.It also contributed to the improvement of prognosis.
Keywords：Primary hepatocellular carcinomaTransarterial chemoembolizationDrug-eluting microspheresIodized oilApatinib
Publication Date：2024-02-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 5-8 )