Effect of ginkgo biloba leaf extract on the pharmacokinetics of piracetam in rats
YANG Lin
ZHU Li-ping
Abstract：Objective:To investigate the effect of single-dose and multi-dose ginkgo biloba leaf extract on the phar-macokinetics of piracetam in rats.Methods:18 Male SD rats were randomly divided into control group(n=6),single-dose ginkgo biloba leaf extract group(n=6)and multiple-dose ginkgo biloba leaf extract group(n=6).After oral administration of Ginkgo biloba extract,piracetam was administered via tail vein injection at a dose of 50 mg·kg-1.The concentration of piracetam in rat plasma was detected.The pharmacokinetic parameters were calculated by DAS and analyzed statistically.Results:Compared with the control group,multi-dose ginkgo biloba leaf extract significantly decreased the AUC of piracetam by 60%,MRT by 50%and T1/2z by 47%and increased the clearance rate by 154%(P<0.05).Conclusion:Multiple interventions with Ginkgo biloba leaf extract significantly reduce the plasma exposure of piracetam in rats and significantly accelerate the elimination rate of the drug in rats.The drug-drug interaction should be considered when piracetam is used in combination with ginkgo biloba extract clinically.
Keywords：PiracetamGinkgo biloba leaf extractPharmacokineticsHPLCSafety
Publication Date：2023-12-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 418-421 )