Effect of meixartan potassium tablet combined with tolvaptan on vascular function in patients with hypertension complicated with heart failure

ZHU Pei-lin; ZHANG Qing-wen; LI Xiao-shan

doi:10.3969/j.issn.1672-8157.2023.06.013

Abstract：Objective:To investigate the effect of meixartan potassium tablet combined with tolvaptan on vascular function in patients with hypertension complicated with heart failure.Methods:A total of 202 patients with hypertension complicated with heart failure were divided into a control group and an observation group.The patients in the control group were treated with tolvaptan,and patients in the observation group with meixartan potassium tablets on the basis of the control group.The blood pressure variability,vascular endothelial function,vascular elasticity function,cardiac function,clinical efficacy and drug safety were compared between the 2 groups.Results:After treatment,the 24 h average SBP,daytime average SBP,night average SBP,morning average SBP,24 h average DBP,daytime average diastolic blood pressure,night average diastolic blood pressure,morning average DBP were all decreased,and the observation group had greater decreases in the above parameters than the control group(P<0.05).The RHI,NO and FMD of the observation group were higher than those of the control group[(1.89±0.11)%and(2.25±0.45)%,t=7.810,P<0.05;(63.83±11.56)μmol·L-1 and(72.18±12.76)μmol·L-1,t=4.873,P<0.05;(7.15±2.03)%与(9.05±1.57)%,t=7.440,P<0.05]and lower levels of ET-1 in the control[(66.13±6.34)%与(50.33±6.43)%,t=17.584,P<0.05].The improvement of vascular elasticity function and cardiac function in the observation group was higher than that in the control(P<0.05).The curative effect of the observation group was better than that of the control(P<0.05).There was no significant difference in the frequency of adverse drug reactions between the 2 groups(P<0.05).Conclusion:Measartan potassium tablet combined with tolvaptan can significantly improve the clinical efficacy,promote the repair of vascular endothelial cell injury and improve the vascular function of patients.