Clinical efficacy of Kuntai capsule in patients with menopausal syndrome after operation for malignant gynecological tumors
TANG Lin
JIN Zhi-yi
ZHANG Feng-ying
SHAO Xiu-lan
Abstract：Objective:To investigate the effect of Kuntai capsule on endocrine function and quality of life in patients with menopausal syndrome after operation for malignant gynecological tumors.Methods:A total of 154 patients with menopausal syndrome after operation for malignant gynecological tumors admitted to our hospital from May 2019 to September 2023 were selected and grouped using random number table methods,with 77 in each group.The patients in the control group were conventionally treated and those in the study group with addition of Kuntai capsule.Then the clinical outcomes,clinical symptom scores,sex hormone,endocrine,and quality of life scores were compared between the 2 groups.Results:The study group reported a higher clinical efficacy rate as compared to the control(100.00%vs 84.42%,P<0.05).A reduction in Kupperman Menopause Index(KMI)score was observed in all patients after treatment,and study group scored lower than the control[(10.92±2.77)vs(15.28±2.85),P<0.05].An increase in β-endorphin(β-EP)and 5-hydroxytryptamine(5-HT)were detected in all patients after treatment,and study group showed higher β-EP and 5-HT levels as compared to the control[(155.17±28.45)pg·mL-1 vs(138.62±27.59)pg·mL-1,(97.22±6.41)μg·L-1 vs(86.55±6.04)μg·L-1,P<0.05].After treatment,an increase in estradiol(E2)and a reduction in luteinizing hormone(LH)were observed in all patients,and E2 and LH levels were(31.83±13.39)pg·mL-1 and(30.15±10.02)U·L-1 in study group,which yielded no statistical difference with thsoe of(31.90±13.74)pg·mL-1 and(30.48±10.26)U·L-1 in control group(P>0.05).Scores of vasomotor diastolic,physiological,sexual life and psychological dimensions showed an increase in all patients after treatment,and study group scored(12.46±2.58),(25.90±3.67),(7.62±2.69),and(14.42±2.62)on above four dimensions,which were higher than(10.94±2.33),(20.88±3.49),(6.14±2.55)and(13.02±2.48)of the control group(P<0.05).Conclusion:Kuntai capsule can effectively improve endocrine function and quality of life in the treatment of menopausal syndrome after operation for malignant gynecological tumors.
Keywords：Malignant gynecological tumorMenopausal syndromeKuntai capsuleRemifeminEndocrine functionQuality of life
Publication Date：2023-12-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 386-389 )