Distribution,drug resistance and risk factors of multi-drug resistant bacteria in northern Sichuan
HUANG Jiang-hua
GUO Wei
YANG Tao
HE Xiao-hua
LI Jia
XIE Xiao-xia
Abstract：Objective:To analyze the distribution,drug resistance and risk factors of multi-drug resistant bacteria infection in northern Sichuan.Methods:The multi-drug resistant bacteria isolated from all kinds of samples of hospitalized patients from 2020 to 2022 were selected as the research objects.The distribution and drug resistance of multi-drug resistant bacteria were analyzed.The risk factors of multi-drug resistant bacteria infection were analyzed by single factor and multi-factor logistic regression.Results:A total of 4 287 non-repeat strains(48.39%)were isolated from all samples in this study,of which 19.17%(822/4 287)were multi-resistant.A total of 232(28.22%)strains of Escherichia coli were found to be multi-drug resistant.The most common multi-drug resistant strains were isolated from sputum(49.57%)and ICU(37.71%).Multivariate regression analysis showed that ICU admission(OR = 3.904,95%CI:1.989-7.662),duration of disease(≥3 months)(OR=4.250,95%CI:1.895-9.531),invasive procedures(OR = 4.572,95%CI:1.911-10.938)and antibiotic use(≥3 classes)(OR = 3.815,95%CI:1.878-7.567)were all risk factors for multidrug-resistant bacterial infection in hospitals in northern Sichuan(P<0.05).Conclusion:Escherichia coli(E.coli)is the most common multi-drug resistant bacteria in hospital.The infection of multi-drug resistant bacteria should be closely monitored,and the preventive and therapeutic measures should be taken according to the characteristics of infection distribution,the results of drug sensitivity test and related risk factors.
Keywords：Multidrug resistant bacteriaDrug resistanceRisk factor
Publication Date：2023-10-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 367-370 )