Analysis of the 77 issues bulletin of National Center for Adverse Drug Reaction Monitoring on adverse reaction involving antibacterial agents
LI Wai
LI Xiu-min
YANG Yu-min
Abstract：Objective:To explore the clinical characteristics and occurrence patterns of adverse drug reactions(ADRs)of antimicrobial agents in Chinese Adverse Drug Reaction Information Bulletin so as to provide guidance for rational clinical use of antibiotics.Methods:The ADR cases were collected from 77 issues of Chinese Adverse Drug Reaction Information Bulletin from November 2001 to June 2020.The number of ADR cases,major manifestations and causes for ADR were summarized.Results:There were 12 varieties of antimicrobial agents and 3 types of medicines in 77 issues of Chinese Adverse Drug Reaction Information Bulletin.The systemic injuries(anaphylactic shock),damage or allergies of the skin and its accessories and respiratory injuries were the major manifestations of ADRs.Conclusion:Reduction of administration frequency and increase of dose each time of clindamycin which was renotified are prone to result in the acute renal function damage,which is most common among the children aged less than 6 years old.Hematuria is more likely to occur when cefradine is given intravenously,which is dominanted by fast-acting type.Gatifloxacin may cause various types of glycemic abnormalities.
Keywords：Chinese Adverse Drug Reaction Information BulletinAntibacterial agentAdverse drug reaction
Publication Date：2023-10-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 364-366 )