Effect of lidocaine combined with dezocine on pain and joint function in patients undergoing total knee arthroplasty
YAN Yao-dong
LI Wei
SHI Qi
SHAN Liang-chang
Abstract：Objective:To investigate the effect of lidocaine combined with dezocine on pain degree and joint function in patients un-dergoing total knee arthroplasty(TKA).Methods:Ninety patients underoing TKA in our hospital from April 2021 to August 2023 were selected and assigned into two groups using random number tablemethod,with 45 cases in each.The patients in the observation group received lidocaine+dezocine+ sufentanil + ondansetronfor analgesia,and those in the control group dezocine + sufentanil + ondansetronfor analgesia.Then the perioperative indexes,visual analogue scale(VAS),and range of motion as well as the safety profiles were compared between the two groups.Results:The dosage of sufentanil at 24h and 48h after operation in the observation group((75.39±7.36)mL,(127.94±13.12)mL)was less than that in the control group((84.21±6.98)mL,(146.45±14.77)mL),and the number of press and effective press of patient-controlled analgesia in the observation group((18.26±3.74)(12.96±2.98)times)was less than that in the control group((22.95±4.09)(16.49±3.87)times),the difference was statistically significant(P<0.05).At 24h and 48h after operation,the knee joint activity in the observation group((82.91±7.09)° and(85.16±7.74)° respectively)was higher than that in the control((77.39±6.97)° and(79.34±6.36)° respectively),and the difference was statistically significant(P<0.05).The effects of different analgesia methods and time on the visual analogue scale(VAS)of patients were interactive P<0.05).In the resting state and exercise state,the VAS scores at 12 h(T1)and 24 h(T2)in the observation group were(2.36±0.46)and(2.96±0.63)respectively,which were lower than those in the control group((2.53±0.64)and(3.16±0.76)respectively),and the differences were statistically significant(P<0.05).Conclusion:Application of lidocaine combined with dezocine in patients undergoing TKA can effectively reduce the amount of sufentanil and the number of compressions of the analgesic pump,alleviate postoperative pain,and improve joint range of motion and decrease the incidence of adverse effects.
Keywords：Total knee arthroplastyLidocaineDezocinePainJoint function
Publication Date：2023-10-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 312-315 )