Literature analysis of platelet reduction induced by cefoperazone sodium and sulbactam sodium in 66 cases
TANG Cai-li
WANG Hong-wei
JING Qie
GONG Ya-jun
YANG Hong-zhong
QIAO Yi
WANG Jing-wen
Abstract：Objective:To analyze the incidence and clinical characteristics of adverse death reaction(ADR)induced by Sulbactam and Cefoperazone to provide reference for clinical safe medication.Methods:Embase,PubMed,CNKI,Wanfang and Weipu databases were searched using the key words of Sulbactam and Cefoperazone,thrombocytopenia.The relevant case reports in domestic and foreign countries were collected for analysis and summary.Results:A total of 51 valid literatures including 61 patients with 66 ADR were selected.Among the 61 patients,the males were more than females(38 males and 23 females).Of all the ADR events,80 had main affection of the organ system and clinical manifestations,of which 44 had general manifestations(55.00%)and 36 severe ones(45.00%).The 66 cases of ADR occurred in 10 minutes to 14 days after administration.64 patients(96.97%)were cured or improved after drug withdrawal or symptomatic treatment,and 2(3.03%)died.ADR occurred in 45 of 61 patients after administration of Sulbactam and Cefoperazone,and their platelet count increased or returned to normal value after treatment.Conclusion:The clinical manifestations of thrombocytopenia caused by Sulbactam and Cefoperazone are various and easy to be ignored.Clinical pharmacists should strengthen the monitoring of drug use and detect ADR in time.Meanwhile,they should take appropriate prevention and treatment measures to ensure drug safety.
Keywords：Sulbactam and cefoperazoneThrombocytopeniaAdverse drug reactionLiterature analysis
Publication Date：2023-08-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 278-282 )