Retrospective analysis of 391 cases of new and severe adverse drug reactions reported in our hospital
ZHANG Kai
WU Yi
WEi Hao-jie
WANG Xiao-juan
CHEN An
WEI Feng
Abstract：Objective:To analyze the new and serious adverse drug reactions(ADR)in Fuyang People's Hospital,and to provide reference for the safe,rational and effective use of drugs in clinic.Methods:Retrospective analysis was used to collect 391 cases of new and serious ADRs reported in Fuyang People's Hospital from January 2020 to December 2022.The patients'age,gender,drug dosage form,route of administration,drug type,system/organ involved in adverse reactions,clinical manifestations,outcome,correlation and occupation of reporting staff were statistically analyzed.Results:Among the 391 cases reported,210 were female and 181 were male.The proportion of females was slightly higher than that of males(1.16:1).Patients aged 60-69 years were the majority(24.80%(97/391)),followed by patients aged 50-59 years(24.55%(96/391)).The drug dosage forms involved were mainly powder injection(42.97%(168/391)),injection(30.69%(120/391))and tablet(16.11%(63/391)).The main routes of adminis-tration involved were intravenous drip(67.01%(262/391))and oral administration(24.3%(95/391)).The drugs involved were mainly anti-tumor agents(31.97%(124/391)),anti-infective agents(14.83%(58/391)),cardiovascular system drugs(13.04%(51/391)),propri-etary Chinese medicines and others(10.23%(40/391)).The distribution and clinical manifestations of adverse reactions were mainly in the blood system and digestive system.Among them,more than 90%were improved or cured,and the correlation evaluation was mainly possible(31.46%(123/391))and very likely(61.63%(241/391)).The most ADRs were reported by pharmacists(49.87%(195/391)),followed by doctors(46.04%(180/391)).Conclusion:In this study,the new and serious ADRs were selected for sta-tistical analysis.Although the proportion of each data was slightly different,the overall difference was not much.Anti-tumor drugs,anti-infective drugs,cardiovascular drugs,proprietary Chinese medicine preparations are still the key varieties of ADR monitoring.Elderly patients are the key objects of drug monitoring and should be alert to adverse reactions of injections.
Keywords：Adverse drug reactionNew adverse drug reactionSerious adverse drug reactionRetrospective analysis
Publication Date：2023-08-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 263-268 )