Clinical efficacy and safety evaluation of Tiggio combined with cisplatin in treatment of patients with HER-2 negative gastric cancer
WANG Xue
ZHAO Hong-ying
LI Wen-guang
ZHANG Gai-Qin
YANG Huan
Abstract：Objective:To investigate the impacts of tegafur,gimeracil and oteracil porassium capsules combined with cisplatin chemotherapy on the expressions of serum carbohydrate antigen(CA)724 and vascular endothelial growth factor(VEGF)in patients with human epidermal growth factor receptor-2(HER-2)negative gastric cancer.Methods:Eighty patients with HER-2 negative gastric cancer admitted to our hospital were enrolled in this study and randomized into the control group and SP group,with 40 in each.The patients in the control group were treated with cisplatin combined with fluorouracil,and those in the combined group with tegafur,gimeracil and oteracil porassium capsules combined with cisplatin.The immune functions(CD4+,CD3+,CD4+/CD8+),the levels of serum CA724 and VEGF,clinical efficacy,survival rate and incidence of adverse reactions were compared between the 2 groups.Results:The levels of CD4+,CD3+,CD4+/CD8+,serum CA724 and VEGF in both groups were obviously decreased after treatment than before(P<0.05).As compared to the control group,the CD4+,CD3+,CD4+/CD8+ in SP group were obviously increased,and the levels of serum CA724 and VEGF were obviously decreased in the combined one(P<0.05).The disease remission rate in the combined group(62.50%)was obviously higher than that in the control(40.00%)(P<0.05).The patients were followed up for 2 years,and 15 patients in the control group survived,accounting for 37.50%while 24 patients in SP group survived,accounting for 60.00%.Log-rank test showed that there was a statistically obvious difference in the cumulative survival rate between the two groups(χ2 = 6.125,P = 0.013).However,there was no obvious difference in the overall incidence of adverse reactions such as oral ulcers,nausea and vomiting,leukopenia and bone marrow suppression between the 2 groups(P>0.05).Conclusion:Tegafur,gimeracil and oteracil porassium capsules combined with cisplatin chemotherapy for patients with HER-2 negative gastric cancer can effectively regulate serum CA724,VEGF levels and immune function,and improve the survival rate.Meanwhile,it is safe and effective.
Keywords：HER-2-negative gastric cancerCisplatinTegafurGimeracil and oteracil porassium capsuleCarbohydrate antigen 724Vascular endothelial growth factor
Publication Date：2023-08-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 226-230 )