Masimo SedLine monitoring-guided use of dexmedetomidine combined with propofol in termination of pregnancy

MA Li; XU Fen-lan; LEI Na-na; YOU Jia

doi:10.3969/j.issn.1672-8157.2023.04.002

Abstract：Objective:To study the application of Masimo SedLine monitoring-guided use of dexmedetomidine combined with propofol in termination of pregnancy and the difference in serum cortisol(COR)and epinephrine(E)levels.Methods:In this study,186 patients who underwent termination of pregnancy in our hospital were selected as the research objects.According to the principle of random grouping,these patients were divided into an observation group and a control group,with 93 in each.The control group received dexmedetomidine combined with propofol anesthesia,while the observation group received Masimo SedLine monitoring-guided use of dexmedetomidine combined with propofol anesthesia.The differences in hemodynamic indicators,anesthesia indicators,pain status,serum COR and E levels,and adverse reactions between the two groups were compared.Results:Compared with the control group,the fluctuation of systolic blood pressure,diastolic blood pressure,blood oxygen saturation and heart rate at different time points in the observation group was significantly lower than that in the control group(P<0.05).There was no statistical significance between the two groups regarding operation time(P>0.05).The amount of propofol used(t = 6.737,P = 0.000),induction time(t = 8.384,P = 0.000)and recovery time(t = 17.090,P = 0.000)in the observation group were lower than those in the control group;VAS scores at different times were significantly lower than those in the control group;there was no significant difference between serum COR and E levels between two groups at T0 stage(P>0.05),but at T6 stage,the serum COR and E levels in both groups were significantly increased,and the serum COR(t = 19.868,P = 0.000)and E(t = 27.134,P = 0.000)levels in the observation group were significantly lower than those in the control group;the incidence of intraoperative body movement(χ2 = 4.731,P = 0.030),respiratory depression(χ2 = 5.142,P = 0.023)and postoperative uterine contraction pain(χ2 = 5.721,P = 0.017)in the observation group were lower than those in the control group.Conclusion:In termination of pregnancy,Masimo SedLine monitoring-guided use of dexmedetomidine combined with propofol anesthesia has significant advantages for patients'anesthesia effect and reduction of serum oxidative stress response.