Two cases of leukopenia, neutropenia with lower percentage induced by moxifloxacin injection
MA Jing
GE Ming-kun
Abstract：Case 1: A 81-year-old female patient was admitted to hospital because of cough, expectoration for ten days. Lab test showed that the white blood cell count (WBC) was 6.42 × 109·L-1, the neutrophilic granulocyte count (NEUT) was 3.85 × 109·L-1and the neutrophil percentage (N%) was 59.9%. And then moxifloxacin injection (0.4 g, qd) were intravenously given to the patient. Ten days later, blood routine test showed WBC was 2.96 × 109·L-1, NEUT was 0.97 × 109·L-1and N% was 32.82%. Recombinant human granulocyte stimulating factor injection was given to her immediately without discounting moxifloxacin. After 5 days, WBC, NEUT and N% returned to the normal range. Case 2: A 42-year-old female patient was admitted to hospital because of cough and expectoration for two days. Lab test showed that WBC was 7.73 × 109·L-1, NEUT was 5.06 × 109·L-1and N% was 65.4%. Eight days after being treated with moxifloxacin injection (0.4 g, qd, ivgtt), her blood routine test showed that WBC was 3.94 × 109·L-1, NEUT was 1.27 × 109·L-1and N% was 32.22%. Moxifloxacin was stopped immediately. Three days later, WBC, NEUT and N% returned to the normal range. Leukopenia and neutropenia induced by moxifloxacin was considered by clinical pharmacists according to analysis on ADR revelance evaluation and drug action.
Keywords：Moxifloxacin injectionLeukopeniaNeutropeniaDecreased of neutrophil percentageAdverse drug reaction
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 311-313 )