Studies on the relationship between serum uric acid and plasma concentration of pyrazinamide in patients with tuberculosis
CHEN Ming
WU Ke
WU Shou-rong
ZHAO Guan-ren
Abstract：Objective: To analyze the relationship between serum uric acid and concentration of pyrazinamide in tuberculosis patients for initial treatment. Methods: According to the enrolled and excluded criterion, 143 cases of tuberculosis including 102 males (71.33%) and 41 females (28.67%) were collected. The blood samples were obtained 2 h after taking pyrazinamide from patients who had been taken pyrazinamide for 5 – 7 days. The plasma concentrations of pyrazinamide were detected by high performance liquid chromatography tandem mass spectrometry. The serum uric acid concentration was detected by our laboratory. SPSS19.0 statistical software was employed to analyze the data using chi-square or t test and it was defined as statistical significance if P < 0.05. Results:88.8% of tuberculosis patients had hyperuricemia after taking pyrazinamide. And hyperuricemia had nothing to do with sex, age, weight and the concentration of pyrazinamide. Hyperuricemia occurred one week after taking pyrazinamide. Although the low concentration of pyrazinamide could delay the onset of hyperuricemia, it couldn't reduce the plasma concentration of uric acid. Conclusion: Most of tuberculosis patients developed hyperuricemia after taking pyrazinamide, which had no relationship with plasma concentration of pyrazinamide.
Keywords：TuberculosisPyrazinamidePlasma concentrationUric acid
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 274-276 )