One case of drug eruption induced by febuxostat and literature review

YUAN Wei; LIU Wei; LI Yun-jing

doi:10.3969/j.issn.1672-8157.2018.03.018

Abstract：One 72-year-old man with gout was treated with febuxostat 40 mg, once daily. On the 17thday, the dose of febuxostat was reduced to 20 mg once daily by himself. On the 25thday, the patient developed itching all over the body and light erythema on trunk. And then the patient further developed desquamation of skin on feet and hands. Febuxostat was withdrawn immediately. Six days later, erythema on trunk was relieved while itching all over the body and desquamation of skin on feet and hands were still obvious. Then the patient was treated with compound glycyrrhizin tablets (25 mg, tid), loratadine tablets (10 mg, qd) and prednisone tablets (30 mg, qd) as an out-patient and was hospitalized one day later without obvious improvement. After admission, lab test showed HLA-B*5801 genotyping was positive. And diphenhydramine injection (20 mg, qd, im), compound glycyrrhizin injection (40 mL, qd, ivgtt), loratadine dispersible tablets (10 mg, qd) and compound flumethasone ointment (external use once daily) were given to him for 8 days. Itching all over the body was gradually disappeared and he was discharged with desquamation on feet and hands. Treatment of loratadine dispersible tablets, compound glycyrrhizin capsules and compound flumethasone ointment was continued for 7 days out of the hospital. One month later, he told us in the follow-up call that he was completed improved 2 weeks after being discharged.