Pharmaceutical care on a case of severe infection in multiple organs caused by extensively drug-resistant Acinetobacter baumannii
MA Jing
XU Jia-bing
Abstract：One 65-year-old female patient was hospitalized mainly because of craniocerebral injury and bleeding for 13 days after car accident and fever for 3 days. The patient was diagnosed as multiple injuries, severe craniocerebral injury, intracranial infection, pulmonary infection, etc. After admission, the patient was treated with meropenem and vancomycin for anti-infection and sodium valproate for epilepsy prevention. And then, vancomycin was replaced with cefoperazone sulbactam because repeated cerebrospinal fluid culture and sputum culture showed extensively drug-resistant Acinetobacter baumannii. But the patient developed epileptic seizure with uncontrolled infection. Clinical pharmacists evaluated the previous treatment and suggested to add minocycline capsules for anti-infection, increase the dosage of sodium valproate or change the antiepileptic drugs for anti-epilepsy. The patient refused new antibacterial regime due to economic reasons. Pharmacists then optimized the anti-infective regime according to the PK/PD theory and gave pharmacological care to the patient at the same time. Epilepsy was controlled with high dose of sodium valproate while infection remained uncontrolled. And the patient was discharged automatically.
Keywords：Extensively drug-resistant Acinetobacter baumanniiClinical pharmacistDrug analysisPharmaceutical care
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 151-154 )