A case of diarrhea and severe hyponatremia caused by pituitrin
WANG Zhe
REN Yuan-qin
SHU He
ZHANG Li
ZHANG Ping
HUO Kun
Abstract：A 52-year-old woman was hospitalized mainly because of repeated cough and expectoration over 50 years, aggravation with blood in phlegm for 2 days. The admission diagnosis was chronic obstructive pulmonary disease and infection, bronchiectasis with hemoptysis. The blood biochemical examination results showed the serum sodium was 141.1 mol·L-1. The hemoptysis volumn was 20 mL per day, so pituitrin was used to stop bleeding. On the 9thday, the patient developed nausea and vomitting. The vomit was stomach contents. After inquiry, clinical pharmacists learned that the patient developed diarrhea without abdominal pain, water stool, 5 - 6 times per day on day 2 after using pituitrin. Blood biochemical test showed that the serum sodium was 111.1 mol·L-1, wihich could be considered as severe hyponatremia. And then the dose of pituitrin was decreased. Symptomatic treatement including slow sodium supplementation, antidiarrheal, antiemetic and so on was given to the patient simultaneously. Four days later, the blood sodium rose to 138.9 mmol·L-1. After 14 days of treatment, the patient was discharged with a stable condition.
Keywords：PituitrinDiarrheaHyponatremiaAdverse drug reaction
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 128-130 )