One case of hypocalcemia and hypokalemia induced by zoledronic acid and literature review
LI Jiu-xu
TANG Zhi-hui
Abstract：One case of 24-year-old female patient diagnosed as priamry hyperparathyroidism and parathyroid gland adenoma. After admission to hospital, the patient was administrated zoledronic acid injection 5 mg once intravenously because of high blood calcium. 22 hours after administration, the patient had a muscular soreness, numbness of limbs, tetany, dyspnea, the facial nerve taps test and beam arm pressure test was positive, the blood calcium 2.05 mmol·L-1, potassium 3.41 mmol·L-1, hypocalcemia and hypokalemia gradually increased. 3 days after administration, the minimum serum calcium was 1.47 mmol·L-1, serum albumin was normal. 4 days after administration, the minimum serum potassium was 2.79 mmol·L-1. The patients was given calcium, potassium and other symptomatic treatment. 5 days after administration, the body facial nerve taps test and beam arm pressure test were negative. 6 days after administration, the result of recheck showed the serum calcium was 2.30 mmol·L-1, the serum potassium was 2.99 mmol·L-1, obviously improved. The patient was transferred to general surgery department for surgical treatment.
Keywords：Priamry hyperparathyroidismZoledronic acidHypocalcemiaHypokalemiaAdverse drug reaction
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 123-126 )