Pharmaceutical care on a patient with PBC, hypercholesterolemia and severe skin pruritus
ZHU Hong
CHEN Xi-cui
DU Wei
ZHAO Qing-guo
Abstract：One 31-year-old female patient was hospitalized mainly because of skin itching for two years and aggravation for 2 months. The patient was diagnosed as PBC and hypercholesterolemia. But autoimmune hepatitis was not excluded. Then the patient was given ursodesoxycholic acid capsules, compound glycyrrhizin injection, atorvastatin calcium tablets and chlorpheniramine maleate tablets. But the symptom of itching was not improved. Chlorpheniramine maleate tablets was changed to sertraline hydrochloride tablets according to the suggestion of clinical pharmacist. And then itching improved while liver injury appeared. Considered that the liver injury was possibly caused by the drug interaction of atorvastatin calcium tablets and sertraline hydrochloride tablets, clinical pharmacist suggested changing atorvastatin calcium tablets to rosuvastatin calcium tablets and reducing the dose of sertraline hydrochloride tablets. Clinical pharmacist provided pharmaceutical care and intervention including selection of medicine for hypercholesterolemia, the effectiveness evaluation of the treatment of itching, the medicine interaction. After the therapy, the patient was discharged with a stable condition.
Keywords：Primary biliary cirrhosisStatinsClinical pharmacistPharmaceutical careAdverse drug reaction
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 89-91 )