Clinical analysis of 1946 cases of adverse drug reactions associated with chemotherapy in cancer patients
WANG Rui-qing
ZHANG Yan-hua
LIU Hong
Abstract：Objective: To analyze the incidence and influence factors of adverse drug reaction (ADR) in cancer patients, and provide an effective basis for rational use of drugs in clinical oncology. Methods: The adverse drug reaction reports in our hospital during 2011 – 2016 were analyzed retrospectively, including the age and gender of the patients, the route of administration, the classification and ranking of drugs causing ADR, and the type of ADR. Results: There were 1946 cases of ADR in 2011 – 2016. In 6 years, the proportion of men and women was 1 : 1.02; the age of patients with ADR mostly concentrated in the 51 – 60 years old (590 cases, 30.32%); paclitaxel associated ADR were the most (328 cases, 11.57%), the most route of administration of those ADRs was intravenous infusion (2338 cases, 82.47%); the system and organ damages were involved in 2696 cases of ADR, including systemic damage, blood system damage, damage of skin and its accessories, etc. Conclusion: The clinical data should be combined with the results of relevant data, and the related factors of ADR in the process of cancer treatment should be paid attention to. The regular monitoring and reporting should be paid attention in order to reduce the occurrence of ADR.
Keywords：Anticancer drugsAdverse drug reactionRational drug use
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 36-39 )