One case of severe acute pancreatitis suspected to be induced by glucocorticoid
REN Yuan-qin
WANG Zhe
ZHANG Li
ZHANG Cheng-dong
SHU He
Abstract：One 67-year-old male patient was admitted because of progressive dysuria, numbness and weakness of both lower extremities for 5 days, and was diagnosed with myelitis. This patient was well healthy before, and denied a history of allergies to drugs and food. A high-dose methylprednisolone pulse therapy was given in the initial treatment phase, and then gradually reduced to low-dose orally. After 26 days of treatment, some symptoms of abdominal pain, and diarrhea appeared on this patient, and then acute pancreatitis was diagnosed with a high level of serum amylase (553 U·L-1) and an abdominal CT showing a slightly plump pancreas. The acute pancreatitis was considered to the adverse drug reaction of methylprednisolone except other reasons of primary diseases and medicines. Then the methylprednisolone was stopped, and dexamethasone, esomeprazole, octreotide, ulinastatin, and aminoacid injections were given in the treatment of acute pancreatitis. In the subsequent treatment, the condition of pancreatitis took a turn for the worse rapidly with multiple organ failures. Finally, this patient gave up his treatment and discharged from hospital on the 34th day.
Keywords：GlucocorticoidMethylprednisoloneAcute pancreatitisAdverse drug reaction
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 381-384 )