Analysis of the utilization of carbapenem antibiotics and the correlation with drug-resistance in our hospital from 2012 to 2016
XU De-duo
CHEN Xian-feng
ZHANG Li
ZHOU Xun
JIN Xiao-ling
TAO Xia
Abstract：Objective: To analyze the correlation between the utilization of carbapenem antibiotics and the drug-resistance rates of some key gram-negative bacteria in our hospital, and provide a theoretical basis for improving the rational use of carbapenems. Methods: The data of consumption fee, DDDs, the DDDs proportion in all antibiotics of carbapenem, and the drug-resistance rates of four gram-negative bacteria to carbapenem from 2012 to 2016 were retrospectively analyzed, and the correlation between drug-resistance rates and drug use was conducted by linear regression. Results: During the past five years, the consumption fee, DDDs, and the DDDs proportion in all antibiotics of carbapenem increased 97.6%, 111% and 41.5%, respectively. The drug-resistant rate of Acinetobacter baumanii to carbapenem had a significant positive correlation with the DDDs proportion of carbapenem in all antibiotics (r = 0.888, P < 0.05). All the drug-resistance of Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumonia to carbapenem did not have significant correlation with the DDDs proportion (P > 0.05). Conclusion: The consumption of carbapenem antibiotics had significant effect on the drug-resistance of some gram-negative bacteria, and the use of carbapenems in clinic should be administrated intensively.
Keywords：CarbapenemsDDDsGram-negative bacteriaDrug-resistance
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 361-364 )