The changes of ACE in endotoxin-induced acute lung injury and antagonistic effects of dexamethasone
WENG Cui-lian
LIU Qing-hua
Abstract：Objective: To study the effects of dexamethasone on the changes of serumal angiotensin converting enzyme (ACE) activity in endotoxin (ET)-induced acute lung injury (ALI) and provide references for the choice of the ALI drugs in ckinic. Methods: The 24 rabbits were divided into three groups: saline control group (group A), ET injuried group (group B), dexamethasone + endotoxin group (group C). Rabbit model of ALI was induced by ET administered intravascularly with a dose of ET 700 μg·kg-1. The rabbits in group C were injected with a dose of dexamethasone (5 mg·kg-1) before ET. The changes of blood oxygenation index (PaO2/FiO2) and serumal ACE activity were observed at 0 h, 0.5 h, 1 h, 2 h, 4 h respectively. Results: In group B, PaO2/FiO2 decreased significantly at 0.5 h (265.4 ± 70.2 mm Hg), then gradually increased. In group B, serumal ACE activity significantly increased at 0.5 h (68.39 ± 6.29 u·mL-1), reached at peak at 1 h (80.13 ± 12.97 u·mL-1), gradually decreased after 2 h. In group C, the PaO2/FiO2 also decreased. The activities of serumal ACE were significantly lower than those in group B. The PaO2/FiO2 and the activity of serumal ACE were comparable to group A. Conclusion: Dexamethasone can possess some protective effects on ALI by inhibiting serumal ACE activity.
Keywords：Acute lung injuryEndotoxinAngiotensin converting enzymeDexamethasone
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 340-343 )