Study on lung pharmacokinetics of moxifloxacin in pneumonia rats
LI Yi
CHENG Xi
CAO Yu-shu
XU Shi-lin
TONG Wan-ning
GUAN Zhen-biao
ZHUO An-shan
Abstract：Objective: To observe the pharmacokinetic characteristics of gavage moxifloxacin in blood and lung tissues of pneumonia rats. Methods: Streptococcus pneumoniae rats were established. The rats were gavaged moxifloxacin at the dose of 42 mg·kg-1, the blood and lung tissues of pneumonia rats were sampled by microdialysis methods. The free drug concentration of moxifloxacin was determined by HPLC method, and the related pharmacokinetic parameters were calculated. Results: In the blood,the Tmax of the free drug concentration was (1.00 ± 0.00) h, Cmax was (4.83 ± 0.05) mg·L-1. In lung tissues, Tmax was (0.95 ± 0.10) h, Cmaxwas (4.84 ± 0.02) mg·L-1. Then, both fell synchronously, the pulmonary penetration rate of moxifloxacin was (1.256 ± 0.321). The elimination half-life (t1/2) was (2.16 ± 0.12) h in the blood and (3.27 ± 0.48) h in the lung tissues (P < 0.05). The AUC(0-inf) of blood and lung tissues was (16.94 ± 1.52) mg·h-1·L-1 and (18.57 ± 1.17) mg ·h-1·L-1, respectively (P < 0.05). The distribution coefficient (AUClung/AUCblood) was (1.216 ± 0.041). Conclusion: In this dose, the penetration rate of gavage moxifloxacin in lung tissue of pneumonia rats was higher, the concentration of free drugs in blood and lung tissue was higher than MIC and mutant prevention concentration. Moxifloxacin can effectively eliminate Streptococcus pneumoniae, and get better efficacy.
Keywords：MoxifloxacinPneumoniaMicrodialysisPharmacokinetics
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 336-340 )