One case of severe agranulocytosis induced by methimazole
ZHU Man-gang
LI Jun
Abstract：One 65-year-old male patient was diagnosed with hyperthyroidism a month ago. The patient was regularly treated with methimazole 20 mg·d-1. While, blood routine examination was rechecked irregularly during the treatment. Four days ago, the patient had fever, cough, sore throat and other symptoms, with no diagnosis and treatment. The symptoms above repeatedly manifested. Blood routine examination showed that white blood cell count was 1.76 × 109·L-1, neutrophils count was 0.01 × 109·L-1, which was diagnosed with agranulocytosis. Then methimazole was stopped. The protective isolation, recombinant human G-CSF and Diyushengbai tablets for increasing white blood cell count were used. As well as anti-infective therapy were also given. During the period, high fever, sore throat, diarrhea and other symptoms occurred frequently. Blood routine examination showed that the neutrophils count was zero for a week. Then according to the patient's condition, the dosage of recombinant human G-CSF was adjusted, and the anti-infective treatment regimen was adjusted according to the results of pathogens. White blood cell count and neutrophils count recovered to normal range after the 13-day treatment. The condition of patient was stable.
Keywords：MethimazoleHyperthyroidismAgranulocytosisAdverse drug reaction
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 324-326 )