Significance of PK/PD characteristics of piperacillin sodium/tazobactam sodium for optimization of clinical medication regimen
BAI Yan
XIA Lei
CHAI Dong
WANG Rui
WANG Jin
Abstract：Objective: To review the significance of PK/PD characteristics of piperacillin sodium/tazobactam sodium (β-lactamase inhibitor compound preparation) for optimization of clinical medication regimen. Methods: The domestic and foreign literature on the optimal clinical dosing regimen based on the pharmacokinetic and pharmacodynamic characteristics of piperacillin sodium/tazobactam sodium for injection were collected. And then the hot issues of the problem of conventional treatment scheme, the status of PK/PD research, the recommendation of the international and domestic guidelines for the drug regimen, and the optimization of the drug regimen for patients with severe infection were summarized. Results: Increasing maximally fT > MIC was the keypoint to achieve valid therapeutic effect of piperacillin sodium/tazobactam sodium for injection. Some studies showed that prolonged infusion or continuous drip could increase the probability of target attainment of %fT > MIC, reduce patients' death rate, shorten days of hospitalization and improve bacterial clearance rate. Conclusion: Prolonged infusion time or sustained infusion was better way to improve the efficiency of piperacillin sodium/tazobactam sodium for injection than the conventional administration according to the PK/PD theoretical guidance. Compared studies on different drug schemes of piperacillin sodium/tazobactam sodium for injection based on accurate quantification will be the main research direction in the future.
Keywords：Piperacillin sodium/tazobactam sodiumPharmacokineticsPharmacodynamicsClinical medicationOptimization
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 305-309 )