Analysis on 9819 cases of ADR/ADE associated with quinolones in military hospitals
HUANG Cui-li
GUO Dai-hong
ZHU Man
WU Xu
SU Chang
ZHAO Su-yu
MA Liang
ZHAO Peng-zhi
ZHAO Liang
Abstract：Objective: To analyze adverse drug reaction reports and events (ADR/ADE) of quinolones in military hospitals in order to investigate the characteristics and regular patterns of quinolones related ADR/ADE. Methods: With the retrospective method, a total of 9819 ADR/ADE of quinolones case reports were collected from 2009 to 2015 in the database of PLA ADR monitoring center. Age and gender of patients, categories of suspected quinolones, route of administration, dosage form systems/organs involved and clinical manifestations, relevance evaluation and prognosis were analyzed. Results: Among 9819 ADR/ADE reports, the male to female ratio was 1.02 : 1. The average age of the patients was (45.67 ± 22.73) years. Intravenous infusion and injection type was the main administration route and pharmaceutical forms. The ADRs were related to 17 kinds. Levofloxacin related reports were 4660 cases (47.46%), followed by moxifloxacin (1681 cases, 17.12%) and gatifloxacin (1597 cases, 16.26%). A total of 9819 cases of the ADR/ADE involved multiple systems/organs (14740 cases). The most common was the skin and its appendages damage (5731 cases, 38.88%), followed by gastrointestinal system damage (2749 cases, 18.65%) and vascular disorders (2162 cases, 14.67%). Conclusion: The ADR/ADE induced by quinolones involved different age of patients, various drug categories and multiple systems/organs. In order to recognize and treat ADR/ADE in time, drug safety risk prevention should be strengthened in the quinolones application.
Keywords：QuinolonesAdverse drug reactionAdverse drug event
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 293-296 )