One case of rhabdomyolysis and acute renal damage associated with rabeprazole
LIU Hua-qiang
MIAO Ying
CHU Xiao
Abstract：A 75-year-old male patient with a medical history of diabetes mellitus, coronary heart disease and right bundle branch block was given rabeprazole 10 mg po qd for esophagitis. After 2 days, he developed thigh muscle pain and red-brown urine. Laboratory test values were as follows: urinalysis showed that urine occult blood 3+, urine protein 2+; 24-hour urinary protein test displayed that urine protein 287.7 mg·L-1, 24-hour urinary protein 604.17 mg; liver and kidney function test revealed that ALT 32 U·L-1, AST 25 U·L-1, BUN 6.5 mmol·L-1, CR 113 μmol·L-1, CK 302.3 U·L-1; MR exhibited that left medial vastus muscle and partial vastus intermedius were mild swelling with diffuse-patchy hyperintense. Drug induced rhabdomyolysis and acute renal damage were diagnosed. Improving microcirculation, nephroprotection and other symptomatic treatment were given to him. After 10 days, the urin alysis showed that urine occult blood 1+, urine protein was normal; 24-hour urinary protein test displayed that urine protein 145.8 mg·L-1, 24-hour urinary protein 437.4 mg; the discomfort symptoms of lower limb muscle were relieved.
Keywords：Rabeprazole sodiumRhabdomyolysisRenal function damageAdverse drug reaction
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 189-190 )