The Monte Carlo simulation analysis of the curative effect of common antibiotics on hospital-acquired Escherichia coli urinary infection
PING Ping
FU Shi-hui
YIN Hong
XU Yan-ping
PEI Bao-xiang
Abstract：Objective: Based on pharmacokinetic and pharmacodynamic theories, the current study was designed to analyze the curative effect of common antibiotics on hospital-acquired escherichia coli urinary infection by Monte Carlo simulation in order to guide the rational drug application in clinic. Methods: 2014.01 – 2014.06 hospitalized patients (2014-year group) and 2015.01 – 2015.06 hospitalized patients (2015-year group) were selected from 1228 patients with hospital-acquired Escherichia coli urinary infection in our hospital. Six kinds of antibiotics including amikacin, levofloxacin, ciprofloxacin, cefazolin, piperacillin/tazobactam and ceftazidime were analyzed by Monte Carlo simulation (10000 times). And then cumulative fraction of response (CFR) and its change values were calculated. Results: In 2014-year group, CFR values of amikacin (400 mg qd), cefazolin (1000 mg tid), ceftazidime (1000 mg bid) and piperacillin/tazobactam (4500 mg qid PI) were 91.22%, 100.00%, 99.75% and 87.88%, respectively. Compared with 2014-year groups, CFR value of ceftazidime in 2015-year group decreased the most (17.21%), followed by piperacillin/tazobactam (4.14%) and amikacin (2.11%), and that of ceftazidime decreased the least (0.00%). Conclusions: Amikacin (400 mg qd), cefazolin (1000 mg tid) and piperacillin/tazobactam (4500 mg qid, PI) had good curative effect on hospital-acquired escherichia coli urinary infection, among which, cefazolin (1000 mg tid) was the best.
Keywords：Escherichia coliAntibioticsMonte Carlo simulationHospital-acquired urinary infectionCurative effect
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 166-169 )