One case of mental and visual impairment and abnormal liver function induced by voriconazole
FENG Fei-fei
ZHANG Xiao-yun
REN Qiu-xia
XIE Ying
ZHU Hong
ZHAO Mei
ZHAO Qing-guo
Abstract：One 56-year-old male patient was diagnosed as HBsAg positive in a physical examination 20 years ago and the liver function was unknown. The patient took lamivudine for antiviral treatment for 2 years. The patient received intermittent treatment with Chinese patent medicine and herbal medicine in order to protect the liver. The patient was admitted with a complaint of abdominal distension and fatigue, and diagnosed as decompensated hepatitis B cirrhosis with ascites and peritonitis. The patient took voriconazole for pulmonary fungal infection, after 12 days of treatment, the liver enzyme bands increased, at the same time photophobia, tremor and convulsion occured. Monitoring of blood concentration showed voriconazole concentration of 12.64 mg·L-1, 3 days after drug withdrawal, the adverse reactions disappeared, blood concentration reduced to 4.96 mg·L-1.
Keywords：VoriconazoleBlood concentration monitoringAdverse drug reaction
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 128-129 )