Analysis of 935 cases of ADR/ADE reports of ginkgo biloba preparation
LIU Ya-nan
LEI Kai
YIN Xian-guo
ZHAO Li
LIU Dong
Abstract：Objective: To analyze the rule and characteristics of ginkgo biloba preparation, to provide references for clinical use. Methods: Using retrospective studies, 935 cases of ADR/ADE reports collected by Hubei Center for ADR Monitoring from January 2012 to December 2014 were analyzed according to patients' age and gender, dosage and administration, occurrence time, the involvement system and manifestation, nature and causality evaluation and so on. Results: From the analysis of 935 cases of ADR/ADE reports of ginkgo biloba preparation, the ratio of male to female was 1 : 1.35, female were more than male, and the ADR/ADE reports appeared in all age groups, especially old people; the mainly involvement system contained central and peripheral nervous system damage (23.30%), gastrointestinal system damage (19.90%), skin and appendages damage (17.52%), cardiovascular damage (17.01%), systemic damage (12.92%); off-label drug use existed in some cases. A total of 21 severe ADR/ADE cases were reported. Conclusion: The ADR/ADE reports of ginkgo biloba preparation were mainly caused by incorrect dosage, administration rate and so on. The health condition of patients also must be taken into account. To reduce the occurrence of ADR/ADE and ensure the safety of clinical use, it is necessary to refer to patients' ADR/ADE history, control the dosage of utilize and provide timely treatment for ADR in clinical use.
Keywords：Ginkgo biloba preparationADR/ADE reportsClinical application
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 107-110 )