Observation of curative effect of tolvaptan in elderly patients with refractory heart failure
YANG Zhi-jian
YANG Wen
ZHANG Chun-yan
YU Xiao-hong
ZHU Wen-ya
HUANG Xue-fei
Abstract：Objective: To observe the safety and efficacy of tolvaptan in elderly patients with refractory heart failure. Methods: Because of the poor effects of routine treatment, 24 cases of elderly patients with refractory heart failure were added with tolvaptan. Their heart rate (HR), blood pressure (BP), respiratory rate (RR), oxygen saturation of peripheral (SPO2), 24-hour urine, body mass, stroke volume (SV), left ventricular ejection fraction (LVEF), serum sodium (Na), serum potassium (K), type B brain natriuretic peptide (BNP), uric acid, signs and side effects were observed. Results: Tolvaptan could significantly improve the SV [(64.4 ± 11.3) mL vs (59.8 ± 8.6) mL, P < 0.05], LVEF [(48.6 ± 9.1)% vs (36.2 ± 6.5)%, P < 0.05], increase 24-hour urine [(2034.8 ± 492.2) mL vs (1042.5 ± 238.2) mL, P < 0.01], Na [(142.2 ± 9.3) mmol·L-1 vs (127.9 ± 7.6) mmol·L-1, P < 0.05] and SPO2 [(97.4 ± 2.5)% vs (89.2 ± 9.6)%, P < 0.05], lower HR [(92.7 ± 12.2) time·min-1 vs (125.3 ± 18.8) time·min-1, P < 0.05], RR [(20.2 ± 2.6) time·min-1 vs (29.7 ± 5.6) time·min-1, P < 0.05] and BNP [(450.7 ± 65.2) ng·L-1 vs (2200.8 ± 128.5) ng·mL-1, P < 0.01], reduce the moist rales, lower limb edema and body mass, without affecting the blood potassium, blood pressure, uric acid and osmotic pressure. Conclusion: Short time tolvaptan application could improve the heart function of patients with refractory heart failure whose routine treatment were poor, and avoid side effects like rapid increase of serum sodium and so on by close clinical monitoring.
Keywords：TolvaptanRefractory heart failureElderDiuretic
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 72-75 )