Efficacy and safety evaluation of isepamicin combined with ceftazidime in the treatment of patients with advanced age
TANG Yi-ran
TANG Min
Abstract：Objective: To evaluate the efficacy and safety of isepamicin combined with ceftazidime in anti-infectious treatment of patients with advanced age. Methods: From 2014 to 2015, the clinical data of anti-infectious treatment with isepamicin and ceftazidime in the patients with advanced age in our hospital were collected and analyzed by retrospective method. Intravenous infusion of ceftazidime 2-3 g twice daily was given. Intravenous infusion of isepamicin 400 mg once daily was given. The treatment course was 5-17 days. The major indexes were effective rate, pathogens clearance rate, peripheral white blood cell count (the proportion of neutrophils) before and after the treatment and renal function. Results: A total of 58 patients were collected with average of 67.4 years old. The main pathogens in patients were Escherichia coli. The treatment course was 5-17 days. The effective rate was 86.2% (50/58), bacterial clearance rate was 82.4% (14/17). There were significant differences before and after the treatment in the levels of the peripheral white blood cell count and the proportion of neutrophils (P < 0.05). There were no significant differences before and after the treatment in the levels of serum creatinine, estimated glomerular filtration rate or blood urea nitrogen (P > 0.05). Conclusion: Isepamicin combined with ceftazidime for anti-infectious treatment in elderly patients is effective. And this treatment generally dosen't cause renal damage under strict control of drug indications, dosage, administration, treatment course and regular monitoring.
Keywords：Elderly patientIsepamicinCeftazidimeAnti-infective therapyRenal function
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 69-71 )